Oxibendazole
产品说明书
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同义名 : | - |
| CAS号 : | 20559-55-1 | |
| 货号 : | A603471 | |
| 分子式 : | C12H15N3O3 | |
| 纯度 : | 98% | |
| 分子量 : | 249.266 | |
| MDL号 : | MFCD00133728 | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 4 mg/mL(16.05 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Oxibendazole (OBZ) is an anthelmintic drug that has also shown promise in the treatment of malignancies. The growth of the 22Rv1 and PC-3 cell lines, as assessed with a trypan blue exclusion assay, was markedly inhibited by OBZ treatment in vitro, with half-maximal inhibitory concentration values of 0.25 and 0.64 µM, respectively[3]. A paste formulation of oxibendazole at 10 mg/kg also eliminated ascarid eggs from feces of 12 suckling foals. Egg and larval count data on foals in both the critical tests and the clinical trials also indicated oxibendazole was active against Strongyloides westeri. Untoward effects of treatment with oxibendazole were not observed[4]. The pyrantel embonate/oxfendazole and ivermectin/ praziquantel/oxibendazole combinations demonstrated full efficacy against Parascaris spp[5]. The apoptotic effect of oxibendazole on pTr (porcine trophectoderm) and pLE (porcine luminal epithelial) cells is regulated by cell signaling pathways, and thus oxibendazole could influence the connection between the conceptus and the maternal uterus[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.01mL 0.80mL 0.40mL |
20.06mL 4.01mL 2.01mL |
40.12mL 8.02mL 4.01mL |
| 参考文献 |
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