产品说明书

Loxoribine

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Chemical Structure| 121288-39-9 同义名 : RWJ 21757;7-Allyl-8-oxoguanosine;Loxoribinum;Loxoribina
CAS号 : 121288-39-9
货号 : A602237
分子式 : C13H17N5O6
纯度 : 99%+
分子量 : 339.304
MDL号 : MFCD00867591
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(309.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Loxoribine is a guanosine analogue with antiviral and antitumour activity. Loxoribine is an orally bioactive and selective TLR7 agonist[1][2][3].Loxoribine induces DC maturation in human monocyte-derived dendritic cells and stimulates their Th-1 and Th-17 polarising capacity[2].At a concentration of 250 μM for 48 hours, Loxoribine stimulates the maturation of MoDCs, as evidenced by the upregulation of CD80, CD83, CD40, CD54 and CCR7[2].Loxoribine selectively activates cells of the innate immune system through the TLR7/MyD88-dependent signalling pathway[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.74mL

2.95mL

1.47mL

29.47mL

5.89mL

2.95mL
参考文献

[1]Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.

[2]Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33.

[3]Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82.