产品说明书

Almorexant

Print
Chemical Structure| 871224-64-5 同义名 : ACT 078573
CAS号 : 871224-64-5
货号 : A597409
分子式 : C29H31F3N2O3
纯度 : 98%
分子量 : 512.56
MDL号 : MFCD22419385
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(87.79 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.20mL

9.75mL

1.95mL

0.98mL

19.51mL

3.90mL

1.95mL
参考文献

[1]Cruz HG, Hoever P, et al. Assessment of the abuse liability of a dual orexin receptor antagonist: a crossover study of almorexant and zolpidem in recreational drug users. CNS Drugs. 2014 Apr;28(4):361-72.

[2]Malherbe P, Borroni E, et al. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor(OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol. 2009 Sep;76(3):618-31.