同义名 :	叶黄制菌素
	CAS号 :	26791-73-1
	货号 :	A597306
	分子式 :	C15H18O3
	纯度 :	99%+
	分子量 :	246.302
	MDL号 :	MFCD17214852
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Xanthatin is isolated from Xanthium strumarium leaves. Xanthatin exhibits strong antitumor activities against a variety of cancer cells through apoptosis persuasion and shows anti-inflammatory activities by inhibiting PGE2 synthesis and 5-lipoxygenase activity. Xanthatin is against T. b. brucei with an IC50 value of 2.63 µg/mL and exhibits weak irreversible inhibition of parasite specific trypanothione reductase[3]. Xanthatin is a potent and orally active inhibitor of VEGFR2 kinase activity with an IC50 of 3.8 μM and prominently blocks the phosphorylation of VEGFR2 at Tyr951 site. Xanthatin (0-40 μM; 24 hours) has obscure inhibition effect on the proliferation of HUVEC in the absence of VEGF. Xanthatin (5-40 μM; 24 hours) inhibits breast cancer cell proliferation in a dose responsive manner. Xanthatin inhibits HCC1937, MDA-MB-415, SK-BR-3, MCF-7 and MDA-MB-231 with IC50 values of 81 μM, 31 μM, 38 μM, 30 μM, and 17 μM, respectively. Xanthatin (0-10 μM; 24 hours) dose dependently suppresses the phosphorylation of STAT3 (Ser727), at the same time, it also results in a rapid dephosphorylation of down-stream kinases of STAT3, including PI3K and Akt, including PI3K (p-PI3K p85 tyr458) and Akt[4]. Xanthatin significantly inhibited the migration and invasion of human HT-29 and HCT-116 colon cancer cells. Concomitantly, xanthatin promoted complex II activity and oxidative phosphorylation (OXPHOS), resulting in mitochondrial damage and cell death in HT-29 cells. Furthermore, xanthatin inhibited the phosphorylation of mTOR, the phosphorylation of 4E-binding protein 1 (4E-BP1) and c-myc in HT-29 cells[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.06mL 0.81mL 0.41mL	20.30mL 4.06mL 2.03mL	40.60mL 8.12mL 4.06mL

参考文献

[1]Romero M, Zanuy M, et al. Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties. Eur J Med Chem. 2015 Jan 27;90:491-6. [2]Li WD, Wu Y, et al. Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo. Phytomedicine. 2013 Jul 15;20(10):865-73. [3]Nibret E, Youns M, Krauth-Siegel RL, Wink M. Biological activities of xanthatin from Xanthium strumarium leaves. Phytother Res. 2011 Dec;25(12):1883-90 [4]Yu Y, Yu J, Pei CG, Li YY, Tu P, Gao GP, Shao Y. Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10355-64 [5]Li L, Liu P, Xie Y, Liu Y, Chen Z, Geng Y, Zhang L. Xanthatin inhibits human colon cancer cells progression via mTOR signaling mediated energy metabolism alteration. Drug Dev Res. 2022 Feb;83(1):119-130