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Angiotensin II

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Chemical Structure| 4474-91-3 同义名 : 血管紧张素II ;Angiotensin II human;Ang II;Asp-Arg-Val-Tyr-Ile-His-Pro-Phe.;Angiotensin II (human);DRVYIHPF
CAS号 : 4474-91-3
货号 : A594780
分子式 : C50H71N13O12
纯度 : 99%
分子量 : 1046.179
MDL号 : MFCD00161484
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(100.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(2.39 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Angiotensin II is a crucial vasoconstrictor and bioactive peptide of the renin/angiotensin system, playing a key role in human blood pressure regulation primarily through its interactions with G-protein-coupled receptors (GPCRs) AT1R and AT2R. It induces various physiological effects, including sympathetic nervous system stimulation, increased aldosterone biosynthesis and renal functions, and vascular and myocardial thickening due to enhanced collagen synthesis in fibroblasts. Additionally, it stimulates the growth of vascular smooth muscle cells and can lead to vascular fibrosis. Angiotensin II also induces capillary formation from endothelial cells through a LOX-1 dependent redox-sensitive pathway [1][2][3][4].
作用机制 Angiotensin-(1-7) Is an endogenous ligand for the G protein-coupled receptor mas .
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02344602 Type 1 Diabetes Mellitus Phase 4 Completed - Canada, Ontario ... 展开 >> Renal Physiology Laboratory, University Health Network Toronto, Ontario, Canada, M5G 2N2 收起 <<
NCT01923597 Diabetic Nephropathy ... 展开 >> Hypertension 收起 << Phase 2 Completed - Brazil ... 展开 >> Unicamp Campinas, São Paulo, Brazil, 13084-971 收起 <<
NCT01371747 Chronic Kidney Disease ... 展开 >> Hypertension Hyperkalemia 收起 << Phase 2 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.96mL

0.19mL

0.10mL

4.78mL

0.96mL

0.48mL

9.56mL

1.91mL

0.96mL
参考文献

[1]de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.

[2]Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.

[3]Hu C, et al. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50(5):952-957.

[4]Nabah YN, et al. Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Circulation. 2004;110(23):3581-3586.

[5]Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.