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Flumetasone

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Chemical Structure| 2135-17-3 同义名 : Flumethasone;NSC 5402;Locorten;Locacorten;Flucorticin;Flucort;Cortexilar;BRN 5645455;Methagon;Fluvet;Aniprime;Anaprime;RS 2177;U-10974;NSC 54702
CAS号 : 2135-17-3
货号 : A594602
分子式 : C22H28F2O5
纯度 : 98%
分子量 : 410.452
MDL号 : MFCD00056464
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(255.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. Flumethasone, a glucocorticoid, inhibited Nrf2 (Nuclear factor erythroid-2-related factor 2) signaling in A549 and H460 cells by promoting Nrf2 protein degradation. Moreover, flumethasone significantly increased the sensitivity of A549 and H460 cells to chemotherapeutic drugs including cisplatin, doxorubicin and 5-FU. Flumethasone can potentially be used as an adjuvant sensitizer to enhance the efficacy of chemotherapeutic drugs in lung cancer[3]. Administration of flumethasone (3.5 mg i.m.) to six cows on day 260 of pregnancy induced parturition in only one animal. In the other five cows circulating concentrations of epitestosterone and conjugated oestrogens increased to reach maximum values (epitestosterone, 13.73 +/- 2.81 nmol/l; conjugated oestrogens, 33.59 +/- 6.87 nmol/l) 2-3 days after treatment. Concentrations of these steroids were raised as long as the synthetic glucocorticoid was present in the circulation (as judged by depression of cortisol concentrations)[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.18mL

2.44mL

1.22mL

24.36mL

4.87mL

2.44mL
参考文献

[1]Sternbauer K, Luthman J, et al. Flumethasone-induced insulin resistance in calves. Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3.

[2]Sustronck B, Deprez P, et al. Efficacy of the combination sodium ceftiofur-flumethasone in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. Zentralbl Veterinarmed A. 1997 May;44(3):179-87.

[3]Zhou Y, Zhou Y, Wang K, Li T, Yang M, Wang R, Chen Y, Cao M, Hu R. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. Cancer Lett. 2020 Apr 1;474:94-105

[4]Möstl E, Choi HS, Bamberg E. Stimulation of androgen and oestrogen concentrations in plasma of cows after administration of a synthetic glucocorticoid (flumethasone) at the end of gestation. J Endocrinol. 1985 Apr;105(1):121-6