产品说明书

Senkyunolide I

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Chemical Structure| 94596-28-8 同义名 : SEI;SENI;Ligustilidiol;Trans-6,7-dihydroxyligustilide;Ligustilidiol, (Z)-
CAS号 : 94596-28-8
货号 : A594383
分子式 : C12H16O4
纯度 : 99%+
分子量 : 224.253
MDL号 : MFCD20527301
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(468.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Senkyunolide I, a natural product isolated and purified from the roots of Ligusticum chuanxiong hort with anti-oxidation and anti-apoptosis properties, is traditionally used to treat migraine, can reduce the metamorphose damage of the RBC caused by ConA, alleviates the aggregation of the RBC, and protect rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.46mL

0.89mL

0.45mL

22.30mL

4.46mL

2.23mL

44.59mL

8.92mL

4.46mL

参考文献

[1]Hu Y, Duan M, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

[2]Xiong YK, Lin X, et al. Identification of senkyunolide I metabolites in rats using ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry. J Pharm Biomed Anal. 2013 Jul-Aug;81-82:178-86.