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SNAP

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Chemical Structure| 67776-06-1 同义名 : SNAP
CAS号 : 67776-06-1
货号 : A594207
分子式 : C7H12N2O4S
纯度 : 98%
分子量 : 220.246
MDL号 : MFCD00272624
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1135.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(45.4 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 S-Nitroso-N-acetyl-DL-penicillamine is a nitric oxide donor and a stable inhibitor of platelet aggregation[1][2][3][4].Under normoxic conditions at a concentration of 10 mM for 8 hours of action, S-Nitroso-N-acetyl-DL-penicillamine induces about 80% toxicity after 6 hours through the release of nitric oxide (NO)[1].In isolated rat ventricular myocytes, the half-life of S-Nitroso-N-acetyl-DL-penicillamine is approximately 6 hours. At a concentration of 100 μM for 30 minutes, S-Nitroso-N-acetyl-DL-penicillamine caused a sustained decrease in basal pHi in isolated rat ventricular myocytes[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.54mL

0.91mL

0.45mL

22.70mL

4.54mL

2.27mL

45.40mL

9.08mL

4.54mL
参考文献

[1]E. Salas, et al. Comparative pharmacology of analogues of S-nitroso-N-acetyl-DL-penicillamine on human platelets. Br J Pharmacol. 1994 Aug;112(4):1071-6.

[2]Ioannidis I, et al. Enhanced release of nitric oxide causes increased cytotoxicity of S-nitroso-N-acetyl-DL-penicillamine and sodium nitroprusside under hypoxic conditions. Biochem J. 1996 Sep 15;318 ( Pt 3):789-95.

[3]Pravdic D, et al. Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes. Clin Exp Pharmacol Physiol. 2012 Sep;39(9):772-8.

[4]Mang CF, et al. Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP). Br J Pharmacol. 2000 Sep;131(1):94-8.