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L-Ascorbic acid sodium salt

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Chemical Structure| 134-03-2 同义名 : 维生素C钠;抗坏血酸钠 ;Sodium ascorbate;Sodium L-ascorbate;Sodium Vitamin C;Vitamin C sodium salt
CAS号 : 134-03-2
货号 : A587658
分子式 : C6H7NaO6
纯度 : 98%
分子量 : 198.11
MDL号 : MFCD00082340
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(5.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(504.77 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 L-Ascorbic acid sodium salt (Sodium ascorbate) functions as an electron donor and serves as an endogenous antioxidant. This compound specifically inhibits Cav3.2 channels with an IC50 of 6.5 μM, and it is noted for its roles in enhancing collagen deposition and inhibiting elastogenesis[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.05mL

1.01mL

0.50mL

25.24mL

5.05mL

2.52mL

50.48mL

10.10mL

5.05mL
参考文献

[1]Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.

[2]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.

[3]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.

[4]Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.

[5]Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.

[6]Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.