产品说明书

Angiotensin II (3-8), human

Print
Chemical Structure| 12676-15-2 同义名 : -
CAS号 : 12676-15-2
货号 : A586132
分子式 : C40H54N8O8
纯度 : 98%
分子量 : 774.91
MDL号 : MFCD00167496
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 The AT1 receptor is involved in the classical physiological actions of Ang II: regulation of blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT1 receptor belongs to the G protein-coupled receptor (GPCR) superfamily, typically activates phospholipase C (PLC) through the heterotrimeric Gq protein and lacks intrinsic tyrosine kinase activity[1]. Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor. Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances[2]. Angiotensin II-(3-8)-hexapeptide, at the dose of 1 nmol given intracerebroventricularly, only slightly less than angiotensin II (the same dose and route) stimulated exploratory locomotor behaviour in an open field and electromagnetic motimeter. Equimolar doses of angiotensin II-(3-8)-hexapeptide and angiotensin II in improving processes related to learning and memory in rats, the effectiveness is almost identical. So it must be independent of specific angiotensin receptors in brain , which the hexapeptide binds with about 1000 times lower affinity than angiotensin II[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.29mL

0.26mL

0.13mL

6.45mL

1.29mL

0.65mL

12.90mL

2.58mL

1.29mL
参考文献

[1]Elena Kaschina,et al. Angiotensin AT1/AT2 receptors: regulation, signalling and function, Blood Press. 2003;12(2):70-88.

[2]Gardiner SM, et al. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol. 1993 Sep;110(1):159-62.

[3]J J Braszko,et al. Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats. 1988 Dec;27(3):777-83.