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Saikosaponin A

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Chemical Structure| 20736-09-8 同义名 : -
CAS号 : 20736-09-8
货号 : A584273
分子式 : C42H68O13
纯度 : 98+%
分子量 : 780.981
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(134.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities. SSA can suppress angiogenesis and tumor growth by blocking the VEGFR2-mediated signaling pathway[3]. SSa (Saikosaponin A) inhibited IL-1β-induced PGE2 and NO production in a concentration-dependent manner. SSa also suppressed IL-1β-induced MMP1, MMP3, and MMP13 production. Furthermore, SSa significantly attenuated IL-1β-induced phosphorylation levels of NF-κB p65 and IκBα. SSa also up-regulated the expression of LXRα. The inhibition of SSa on PGE2, NO, MMP1, MMP3, and MMP13 production were reversed by LXRα siRNA or GGPP, the inhibitor of LXRα[4]. SSa played a critical anti-inflammatory effect through inhibition of NF-κB and NLRP3 signaling pathways and protected against LPS-induced ALI(acute lung injury)[5]. Saikosaponin A had protective effects against DSS (dextran sulfate sodium)-induced colitis. Saikosaponin A protected DSS-induced colitis through inhibiting inflammatory response[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.28mL

0.26mL

0.13mL

6.40mL

1.28mL

0.64mL

12.80mL

2.56mL

1.28mL
参考文献

[1]Zhou C, Liu W, et al. Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways. Int Immunopharmacol. 2015 Mar;25(1):49-54.

[2]Zhu J, Luo C, et al. Saikosaponin A mediates the inflammatory response by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells. Exp Ther Med. 2013 May;5(5):1345-1350.

[3]Zhang P, Lai X, Zhu MH, Long M, Liu XL, Wang ZX, Zhang Y, Guo RJ, Dong J, Lu Q, Sun P, Fang C, Zhao M. Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway. Front Pharmacol. 2021 Oct 29;12:713200

[4]Gao H, Song Y, Li D, Feng W, Liu J. Saikosaponin A inhibits IL-1β-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXRα. Oncotarget. 2017 Sep 30;8(51):88941-88950

[5]Du ZA, Sun MN, Hu ZS. Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice. Inflammation. 2018 Feb;41(1):193-198

[6]Zhou F, Wang N, Yang L, Zhang LC, Meng LJ, Xia YC. Saikosaponin A protects against dextran sulfate sodium-induced colitis in mice. Int Immunopharmacol. 2019 Jul;72:454-458