产品说明书

Polmacoxib

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Chemical Structure| 301692-76-2 同义名 : CG100649
CAS号 : 301692-76-2
货号 : A580496
分子式 : C18H16FNO4S
纯度 : 97%
分子量 : 361.387
MDL号 : MFCD22570958
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(691.78 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Polmacoxib (CG100649) is a pioneering orally active nonsteroidal anti-inflammatory drug (NSAID) with the unique capability of dual inhibition, targeting COX-2 with an IC50 approximately 0.1 μg/ml and carbonic anhydrase[1]. This first-in-class agent shows promise in inhibiting the growth of colorectal adenomas and tumors in mouse models[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL
参考文献

[1]Kim SH, et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs. 2014;32(6):1105-1112.

[2]Flick AC, et al. Synthetic Approaches to the New Drugs Approved During 2015 [published correction appears in J Med Chem. 2017 Oct 26;60(20):8680]. J Med Chem. 2017;60(15):6480-6515.