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Pivanex

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Chemical Structure| 122110-53-6 同义名 : AN-9;Pivalyloxymethyl butyrate;Pivanex, AN9, pivaloyloxymethyl butyrate, Titan.
CAS号 : 122110-53-6
货号 : A579458
分子式 : C10H18O4
纯度 : 95%
分子量 : 202.248
MDL号 : MFCD00209896
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(519.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Pivanex, a derivative of butyric acid, is an orally active HDAC inhibitor.Pivanex down-regulates BCR-ABL protein and promotes apoptosis. Pivanex has anti-tumour and anti-angiogenic properties[1].At concentrations of 100-500 μM, Pivanex has significant antiproliferative activity on K562 cells, enhancing apoptosis and caspase activity. At a concentration of 200 μM, Pivanex can induce enhancement of the G2-M phase of the cell cycle, moderate enhancement of the S phase, and slight attenuation of the G0-G1 phase[1].Pivanex is selectively toxic to acute leukaemia and drug-resistant primary leukaemia and cancer cell lines[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.94mL

0.99mL

0.49mL

24.72mL

4.94mL

2.47mL

49.44mL

9.89mL

4.94mL
参考文献

[1]Rabizadeh E, et al. Pivanex, a histone deacetylase inhibitor, induces changes in BCR-ABL expression and when combined with STI571, acts synergistically in a chronic myelocytic leukemia cell line. Leuk Res. 2007 Aug;31(8):1115-23. Epub 2007 Jan 30.

[2]Batova A, et al. The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Blood. 2002 Nov 1;100(9):3319-24.

[3]Edwards JD, et al. Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy. J Neuromuscul Dis. 2016 Nov 29;3(4):511-515.