产品说明书

GSK2981278

Print
Chemical Structure| 1474110-21-8 同义名 : -
CAS号 : 1474110-21-8
货号 : A576988
分子式 : C25H35NO5S
纯度 : 99%+
分子量 : 461.614
MDL号 : MFCD29059455
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(227.46 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GSK2981278 is recognized as a potent and selective inverse agonist of RORγ, effectively inhibiting the activation of the IL17 promoter and disrupting RORγ-DNA binding[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.66mL

4.33mL

2.17mL
参考文献

[1]Smith SH, et al. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin. PLoS One. 2016 Feb 12;11(2):e0147979.