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Rottlerin

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Chemical Structure| 82-08-6 同义名 : 粗糠柴苦素 ;Mallotoxin;NSC 94525;Kamalin;NSC 56346
CAS号 : 82-08-6
货号 : A575891
分子式 : C30H28O8
纯度 : 98%+
分子量 : 516.538
MDL号 : MFCD00017361
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(23.23 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rottlerin is a compound extracted from Mallotus Philippinensis, functions as a selective inhibitor of Protein Kinase C (PKC), demonstrating IC50 values of 3-6 μM for PKCδ, 30-42 μM for PKCα,β,γ, and 80-100 μM for PKCε,η,ζ. Its mode of action includes acting as a direct mitochondrial uncoupler and promoting autophagy by acting on a signaling cascade upstream of mTORC1. Furthermore, Rottlerin triggers apoptosis through the activation of caspase 3[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.94mL

0.39mL

0.19mL

9.68mL

1.94mL

0.97mL

19.36mL

3.87mL

1.94mL
参考文献

[1]Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8.

[2]Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77(6):460-70.

[3]Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.