CDDO-Im

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Chemical Structure| 443104-02-7 同义名 : CDDO-Imidazolide; TP-235; CDDO Im, CDDO-Im; RTA-403
CAS号 : 443104-02-7
货号 : A574651
分子式 : C34H43N3O3
纯度 : 98%
分子量 : 541.723
MDL号 : MFCD12756341
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(46.15 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CDDO-Im (RTA-403) functions as an activator of Nrf2 and PPAR, showing high affinity for PPARα and PPARγ with inhibition constants (Kis) of 232 nM and 344 nM, respectively[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.85mL

0.37mL

0.18mL

9.23mL

1.85mL

0.92mL

18.46mL

3.69mL

1.85mL
参考文献

[1]Place AE, et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res. 2003 Jul;9(7):2798-806.

[2]Liby K, et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005 Jun 1;65(11):4789-98.

[3]So JY, et al. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS One. 2014 Sep 17;9(9):e107616.