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BTR-1

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Chemical Structure| 18331-34-5 同义名 : -
CAS号 : 18331-34-5
货号 : A573829
分子式 : C12H11NOS2
纯度 : 99%+
分子量 : 249.352
MDL号 : MFCD01021954
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(100.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BTR-1 is an active anti-cancer agent, causes S phase arrest, and affects DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death. BTR-1 (10, 50, 100, and 250 µM, 5 days) dose-dependently causes cytotoxicity in human leukemic cells, with IC50s of 8 and 6 µM at 48 and 72 h, respectively[1]. BTR-1 is essential to larval midgut epithelial organization during rapid cell proliferation and tissue growth in M. sexta because disruption of such organization and functionality occasioned by the binding of the Cry1A toxins of B. thuringiensis to BTR-1 causes death to the insect[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.05mL

4.01mL

2.01mL

40.10mL

8.02mL

4.01mL
参考文献

[1]Moorthy BT, Ravi S, Srivastava M, Chiruvella KK, Hemlal H, Joy O, Raghavan SC. Novel rhodanine derivatives induce growth inhibition followed by apoptosis. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6297-301

[2]Midboe EG, Candas M, Bulla LA Jr. Expression of a midgut-specific cadherin BTR-1 during the development of Manduca sexta larva. Comp Biochem Physiol B Biochem Mol Biol. 2003 May;135(1):125-37