Ravuconazole

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Chemical Structure| 182760-06-1 同义名 : 立福康唑 ;BMS-207147; ER-30346
CAS号 : 182760-06-1
货号 : A573629
分子式 : C22H17F2N5OS
纯度 : 98%
分子量 : 437.47
MDL号 : MFCD00941002
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(114.29 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ravuconazole displays a broad spectrum of antifungal activity against various fungi including Candida spp., Trichosporon beigelii, CNeoformans, and A. fumigatus. The MIC90 for these fungi ranges from 0.025 to 0.39 mg/mL. It demonstrates enhanced efficacy against strains of Candida krusei, with MICs from 0.05 to 0.39 mg/mL, and shows effective activity against T. mentagrophytes, T. rubrum, M. gypseum, and M. canis, with MICs from 0.05 to 0.39 mg/mL[1]. Ravuconazole is two to four times more potent than itraconazole and about 40 times more effective than fluconazole against yeasts. Both ravuconazole and itraconazole inhibit most aspergilli effectively, with cidal action against half of the isolates. They are also active against hyaline Hyphomycetes, dermatophytes, and dematiaceous fungi but inactive against Sporothrix schenckii and zygomycetes[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.43mL

2.29mL

1.14mL

22.86mL

4.57mL

2.29mL
参考文献

[1]Hata K, et al. In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrumAntimicrob Agents Chemother. 1996 Oct;40(10):2237-42.

[2]Fung-Tomc JC, et al. In vitro activity of a new oral triazole, BMS-207147 (ER-30346)Antimicrob Agents Chemother. 1998 Feb;42(2):313-8.

[3]Hata K, et al. Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosisAntimicrob Agents Chemother. 1996 Oct;40(10):2243-7.