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VO-Ohpic trihydrate

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Chemical Structure| 476310-60-8 同义名 : VO-OHpic (hydrate)
CAS号 : 476310-60-8
货号 : A573257
分子式 : C12H11N2O9V
纯度 : 98%
分子量 : 378.165
MDL号 : MFCD11045907
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(132.22 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

2% DMSO+40% PEG 300+2% Tween 80+water 14 mg/mL

生物活性
靶点

  • PTEN

    PTEN, IC50:35 nM
描述 VO-OHpic, featuring two OHpic ligands and an oxo ligand, is a molecule with substantial steric bulk, suggesting that substrate binding may influence inhibitor binding due to steric hindrance. It markedly inhibits PTEN activity at low nanomolar concentrations (IC50, 46±10 nM), aligning with its previously established potency (IC50, 35±2 nM) in a PIP3-based assay. The inhibition constants Kic and Kiu have been calculated to be 27±6 and 45±11 nM, respectively[1]. VO-OHpic stands out as a notably specific and potent inhibitor of PTEN. It is identified as the most effective inhibitor of PTEN lipid phosphatase activity, with an IC50 value of 35 nM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.22mL

2.64mL

1.32mL

26.44mL

5.29mL

2.64mL
参考文献

[1]Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63.

[2]Rosivatz, E, et al. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006 Dec 15;1(12):780-90.

[3]Zu L, et al. PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. Eur J Pharmacol. 2011 Jan 10;650(1):298-302.