产品说明书

Thalidomide-5-OH

Print
Chemical Structure| 64567-60-8 同义名 : -
CAS号 : 64567-60-8
货号 : A571532
分子式 : C13H10N2O5
纯度 : 95%
分子量 : 274.229
MDL号 : MFCD24386541
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(218.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Thalidomide-5-OH, a derivative of Thalidomide, functions as a cereblon ligand essential for the recruitment of the CRBN protein. By attaching Thalidomide-5-OH to a target protein ligand through a linker, it can be utilized to construct PROTACs, offering a strategy for targeted protein degradation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.65mL

0.73mL

0.36mL

18.23mL

3.65mL

1.82mL

36.47mL

7.29mL

3.65mL
参考文献

[1]Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.