产品说明书
Progesterone
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同义名 : | 孕酮 ;Pregn-4-ene-3,20-dione;Cyclogest;Lutociclina;Hormoflaveine;Progesterone, (9 beta,10 alpha)-Isomer;Progesterone, (17 alpha)-Isomer;Progesterone, (13 alpha,17 alpha)-(+-)-Isomer;Utrogestan;Luteohormone;Crinone;Agolutin;NSC 64377;NSC 9704 |
| CAS号 : | 57-83-0 | |
| 货号 : | A571091 | |
| 分子式 : | C21H30O2 | |
| 纯度 : | 99+% | |
| 分子量 : | 314.46 | |
| MDL号 : | MFCD00003658 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(159 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It is a potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM, an agonist of the membrane progesterone receptors(mPRs), and an antagonist of the σ1 receptor. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
| A2780 cells | Function assay | Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay, IC50=47.863 μM | 18678495 | ||
| CHO cells | Function assay | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay, EC50=2.77 μM | 18307294 | ||
| CV-1 cells | Function assay | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells, EC50=1.5 nM | 9667968 | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00247169 | Cervical Intraepithelial Neopl... 展开 >>asia 收起 << | Phase 2 | Completed | - | Austria ... 展开 >> Dept OB/GYN, Med University of Vienna Vienna, Austria 收起 << |
| NCT01741376 | Cocaine Dependence ... 展开 >> Nicotine Dependence 收起 << | Not Applicable | Terminated(Cocaine use is no l... 展开 >>onger a substance of abuse in our geographic location) 收起 << | - | United States, Minnesota ... 展开 >> University of Minnesota Minneapolis, Minnesota, United States, 55455 收起 << |
| NCT02788097 | - | Terminated(Large and sustained... 展开 >> difference in pregnancy rate) 收起 << | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.18mL 0.64mL 0.32mL |
15.90mL 3.18mL 1.59mL |
31.80mL 6.36mL 3.18mL |
| 参考文献 |
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