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Progesterone

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Chemical Structure| 57-83-0 同义名 : 孕酮 ;Pregn-4-ene-3,20-dione;Cyclogest;Lutociclina;Hormoflaveine;Progesterone, (9 beta,10 alpha)-Isomer;Progesterone, (17 alpha)-Isomer;Progesterone, (13 alpha,17 alpha)-(+-)-Isomer;Utrogestan;Luteohormone;Crinone;Agolutin;NSC 64377;NSC 9704
CAS号 : 57-83-0
货号 : A571091
分子式 : C21H30O2
纯度 : 99+%
分子量 : 314.46
MDL号 : MFCD00003658
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(159 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It is a potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM, an agonist of the membrane progesterone receptors(mPRs), and an antagonist of the σ1 receptor.
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
A2780 cells Function assay Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay, IC50=47.863 μM 18678495
CHO cells Function assay Agonist activity at human TGR5 expressed in CHO cells by luciferase assay, EC50=2.77 μM 18307294
CV-1 cells Function assay Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells, EC50=1.5 nM 9667968
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00247169 Cervical Intraepithelial Neopl... 展开 >>asia 收起 << Phase 2 Completed - Austria ... 展开 >> Dept OB/GYN, Med University of Vienna Vienna, Austria 收起 <<
NCT01741376 Cocaine Dependence ... 展开 >> Nicotine Dependence 收起 << Not Applicable Terminated(Cocaine use is no l... 展开 >>onger a substance of abuse in our geographic location) 收起 << - United States, Minnesota ... 展开 >> University of Minnesota Minneapolis, Minnesota, United States, 55455 收起 <<
NCT02788097 - Terminated(Large and sustained... 展开 >> difference in pregnancy rate) 收起 << - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.90mL

3.18mL

1.59mL

31.80mL

6.36mL

3.18mL
参考文献

[1]Joshi PA, Jackson HW, et al. Progesterone induces adult mammary stem cell expansion. Nature. 2010 Jun 10;465(7299):803-7.

[2]Owen GI, Richer JK, et al. Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem. 1998 Apr 24;273(17):10696-701.