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SKLB-23bb

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Chemical Structure| 1815580-06-3 同义名 : -
CAS号 : 1815580-06-3
货号 : A567414
分子式 : C21H24N4O4
纯度 : 99%+
分子量 : 396.44
MDL号 : MFCD30533607
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(75.67 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SKLB-23bb is a potent and selective HDAC6 inhibitor, showcasing an IC50 of merely 17 nM. It distinguishes itself by being 25 times more selective against HDAC1 (IC50 = 422 nM) and 200 times more selective against HDAC8 (IC50 = 3398 nM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL
参考文献

[1]Yang Z, et al. Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer. J Med Chem. 2016 Feb 25;59(4):1455-70.