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Nardosinone

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Chemical Structure| 23720-80-1 同义名 : 甘松新酮
CAS号 : 23720-80-1
货号 : A565109
分子式 : C15H22O3
纯度 : 99%
分子量 : 250.333
MDL号 : MFCD21363103
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(998.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Nardosinone was isolated as an enhancer of nerve growth factor (NGF) from Nardostachys chinensis. Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway[3]. Nardosinone may reduce the motor and cognitive symptoms in the animal PD model by regulating DRD2 (Dopamine receptor D2) expression[4]. Pretreatment with nardosinone (25, 50, 100, and 200 μmol/L) could significantly inhibit the enlargement of cell surface area induced by AngII. The protective effects of nardosinone might be mediated by repressing the phosphorylation of related proteins in PI3K/Akt and MEK/ERK signaling pathways[5]. Nardosinone promotes cells proliferation and increases cells migration distance in a dose-dependent manner. Nardosinone also induces the selective differentiation of neural stem cells to neurons and oligodendrocytes, as indicated by the expression of microtubule-associated protein-2 and myelin basic protein, respectively. Nardosinone also increases the expression of phospho-extracellular signal-regulated kinase and phospho-cAMP response element binding protein during proliferation and differentiation[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.99mL

0.80mL

0.40mL

19.97mL

3.99mL

2.00mL

39.95mL

7.99mL

3.99mL
参考文献

[1]Li ZH, Li W, et al. Nardosinone improves the proliferation, migration and selective differentiation of mouse embryonic neural stem cells. PLoS One. 2014 Mar 10;9(3):e91260.

[2]Du M, Huang K, et al. Nardosinone protects H9c2 cardiac cells from angiotensin II-induced hypertrophy. J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):822-6.

[3]Li P, Matsunaga K, Yamakuni T, Ohizumi Y. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells. Brain Res Dev Brain Res. 2003 Nov 12;145(2):177-83

[4]Bian LH, Yao ZW, Zhao CB, Li QY, Shi JL, Guo JY. Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor. Evid Based Complement Alternat Med. 2021 Aug 13;2021:6686965

[5]Du M, Huang K, Gao L, Yang L, Wang WS, Wang B, Huang K, Huang D. Nardosinone protects H9c2 cardiac cells from angiotensin II-induced hypertrophy. J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):822-826

[6]Li ZH, Li W, Shi JL, Tang MK. Nardosinone improves the proliferation, migration and selective differentiation of mouse embryonic neural stem cells. PLoS One. 2014 Mar 10;9(3):e91260