产品说明书
ME0328
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同义名 : | - |
| CAS号 : | 1445251-22-8 | |
| 货号 : | A562763 | |
| 分子式 : | C19H19N3O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 321.373 | |
| MDL号 : | MFCD27991291 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 80 mg/mL(248.93 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | ME0328 is recognized as a potent and selective ARTD3/PARP3 inhibitor, active within cellular environments. It demonstrates an ability to inhibit ARTD3's transferase activity, with an IC50 of 0.89±0.28 μM, as determined by in vitro histone H1 modification assays. In A549 human cells, both ME0328 and ME0355, at a concentration of 10 μM, prolong the presence of γH2AX foci, indicative of a delay in DNA double-strand break repair post γ-irradiation of 2 Gy. ME0328 has been characterized through in silico and in vitro analyses to be soluble, capable of cell penetration, and metabolically stable in human liver microsomes and rat hepatocytes[1]. | ||
| 作用机制 | ME0328 targets the nicotinamide binding site.[1] | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.11mL 0.62mL 0.31mL |
15.56mL 3.11mL 1.56mL |
31.12mL 6.22mL 3.11mL |
| 参考文献 |
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