产品说明书
Isoginkgetin
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同义名 : | 异银杏双黄酮 |
| CAS号 : | 548-19-6 | |
| 货号 : | A561680 | |
| 分子式 : | C32H22O10 | |
| 纯度 : | 95% | |
| 分子量 : | 566.511 | |
| MDL号 : | MFCD00597035 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(185.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Isoginkgetin is a MMP-9 inhibitor isolated and purified from the leaves of Ginkgo biloba L., also a Pre-mRNA Splicing inhibitor with IC50 of 30 μM. Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin was also quite effective in inhibiting the activities of Akt and MMP-9 in MDA-MB-231 breast carcinomas and B16F10 melanoma[3]. Isoginkgetin disturbs protein homeostasis, leading to an excess of protein cargo that places a burden on the lysosomes/autophagic machinery, eventually leading to cancer cell death[4]. In vitro, isoginkgetin markedly suppressed the production of IL-1β, IL-6, tumor necrosis factor-alpha, cyclooxygenase-2, inducible NO, and ROS, which are released from LPS-stimulated BV2 cells. Moreover, CM (conditioned medium) from isoginkgetin-treated BV2 cells significantly alleviated SH-SY5Y cell apoptosis and restored cell viability compared to LPS-treated group through the inhibition of p38/NF-κB signaling pathway[5]. Blocking IL-32 alternative splicing by Isoginkgetin resulted in predominant expression of IL-32γ splice variants and cell death in TC (thyroid cancer) cell lines[6]. At 10 uM, isoginkgetin showed the suppressive activity against lymphocyte proliferation induced by Con A or LPS[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.77mL 0.35mL 0.18mL |
8.83mL 1.77mL 0.88mL |
17.65mL 3.53mL 1.77mL |
| 参考文献 |
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