产品说明书

Vindorosine

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Chemical Structure| 5231-60-7 同义名 : Demethoxyvindoline
CAS号 : 5231-60-7
货号 : A560564
分子式 : C24H30N2O5
纯度 : 99+%
分子量 : 426.505
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Vindorosine, a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don, has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.34mL

0.47mL

0.23mL

11.72mL

2.34mL

1.17mL

23.45mL

4.69mL

2.34mL
参考文献

[1]Wu XL, Cheang WS, et al. Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus-derived vindorosine in rat renal artery. Planta Med. 2014 Dec;80(18):1672-7.

[2]Sasaki Y, Kato D, Boger DL. Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues. J Am Chem Soc. 2010 Sep 29;132(38):13533-44.