产品说明书
XMD8-87
 |
同义名 : | ACK1-B19 |
| CAS号 : | 1234480-46-6 | |
| 货号 : | A560552 | |
| 分子式 : | C24H27N7O2 | |
| 纯度 : | 97% | |
| 分子量 : | 445.517 | |
| MDL号 : | MFCD30742941 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 25 mg/mL(56.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tyrosine Kinase nonreceptor 2 (TNK2) is a cytoplasmic kinase also known as ACK1 (activated CDC42-associated kinase) which is part of a family of cytoplasmic tyrosine kinases. TNK2 mutations have been found in renal cancer cells and also in lung, ovarian, and gastric cancers[2]. XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively. XMD8-87 potently inhibits phosphorylation of TNK2 truncation mutations found in solid tumor types. But, it’s very highly cleared in vivo in rodent PK studies[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.24mL 0.45mL 0.22mL |
11.22mL 2.24mL 1.12mL |
22.45mL 4.49mL 2.24mL |
| 参考文献 |
|---|