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Neotuberostemonine

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Chemical Structure| 143120-46-1 同义名 : Tuberostemonine LG;NTS;(+)-Neotuberostemonine
CAS号 : 143120-46-1
货号 : A560253
分子式 : C22H33NO4
纯度 : 98%
分子量 : 375.502
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(133.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Neotuberostemonine, a natural product isolated and purified from the roots of Stemona tuberosa, has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages and demonstrates antitussive properties in guinea pigs.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.32mL

2.66mL

1.33mL

26.63mL

5.33mL

2.66mL
参考文献

[1]Kongkiatpaiboon S, Keeratinijakal V, Gritsanapan W. TLC-image analysis of non-chromophoric tuberostemonine alkaloid derivatives in Stemona species. Nat Prod Commun. 2013 Aug;8(8):1065-8.

[2]Sun H, Dong W, et al. Ultra-performance liquid-chromatography with tandem mass spectrometry performing pharmacokinetic and biodistribution studies of croomine, neotuberostemonine and tuberostemonine alkaloids absorbed in the rat plasma after oral administration of Stemonae Radix. Fitoterapia. 2012 Dec;83(8):1699-705.