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Sennoside A

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Chemical Structure| 81-27-6 同义名 : 番泻叶苷A ;NSC 112929
CAS号 : 81-27-6
货号 : A559275
分子式 : C42H38O20
纯度 : 98%+
分子量 : 862.739
MDL号 : MFCD00151527
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(139.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • MAO

    MAO, IC50:17 μM
描述 Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb. SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities[3]. Sennoside A is a new scaffold for the development of HIV-1 dual RT (Reverse Transcriptase) inhibitors. Sennoside A also affected HIV-1 IN activity in vitro and HIV-1 replication in cell-based assays[4]. Plasma GLP-1 (Glucagon-like peptide-1) and insulin were markedly elevated by SA (Sennoside A) at the dosage of 45 mg/kg/day. Meanwhile, the increased phosphorylation status of EKR1/2 and prohormone convertase 1/3 (PC1/3) proteins were observed in the colon of SA-treated mice[5]. Sennoside A administration markedly improved the indices in T2D mice and obesity-related traits including blood glucose level, body weight, lipid metabolism disorder, and insulin resistance. Sennoside A also reduced inflammation and increased tight junction proteins in the ileum in gene-deficient mice via gut microbiota alteration[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.16mL

0.23mL

0.12mL

5.80mL

1.16mL

0.58mL

11.59mL

2.32mL

1.16mL
参考文献

[1]Kobayashi M, Yamaguchi T, et al. Regionally differential effects of sennoside A on spontaneous contractions of colon in mice. Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):121-6.

[2]Hiraoka A, Koike S, et al. The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase. Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2744-6.

[3]Le J, Ji H, Zhou X, Wei X, Chen Y, Fu Y, Ma Y, Han Q, Sun Y, Gao Y, Wu H. Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound. Front Pharmacol. 2021 Oct 26;12:714586

[4]Esposito F, Carli I, Del Vecchio C, Xu L, Corona A, Grandi N, Piano D, Maccioni E, Distinto S, Parolin C, Tramontano E. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391

[5]Ma L, Cao X, Ye X, Ye J, Sun Y. Sennoside A Induces GLP-1 Secretion Through Activation of the ERK1/2 Pathway in L-Cells. Diabetes Metab Syndr Obes. 2020 Apr 29;13:1407-1415

[6]Wei Z, Shen P, Cheng P, Lu Y, Wang A, Sun Z. Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits. Oxid Med Cell Longev. 2020 Jun 25;2020:2375676