产品说明书

Orobol

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Chemical Structure| 480-23-9 同义名 : -
CAS号 : 480-23-9
货号 : A558329
分子式 : C15H10O6
纯度 : 98+%
分子量 : 286.236
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(174.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Orobol, a natural product isolated and purified from the herb of Wisteria sinensis, has sensitization effect may be by mitochondrial alterations in these cells, produces cisplatin sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway, and regulate PX sensitivity by reciprocally altering the proportion of tubulin isotype expression and PX-induced apoptotic signaling.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.94mL

6.99mL

3.49mL
参考文献

[1]Isonishi S, Saitou M, et al. Differential regulation of the cytotoxicity activity of paclitaxel by orobol and platelet derived growth factor in human ovarian carcinoma cells. Oncol Rep. 2007 Jul;18(1):195-201.

[2]Shiotsuka S, Isonishi S. Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. Int J Oncol. 2001 Feb;18(2):337-42.