Pectolinarigenin

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Chemical Structure| 520-12-7 同义名 : -
CAS号 : 520-12-7
货号 : A557473
分子式 : C17H14O6
纯度 : 99%+
分子量 : 314.289
MDL号 : MFCD00017444
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(111.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Pectolinarigenin is a dual inhibitor of COX-2/5-LOX with anti-inflammatory activity[3]. Pectolinarigenin has potent inhibitory activities on melanogenesis. Pectolinarigenin treatment resulted in growth inhibition and apoptosis induction in melanoma cells, and the potential of pectolinarigenin to impair the migration and invasion of melanoma cells in accordance with the changes in the expression of the associated proteins[4]. Intraperitoneal administrations of pectolinarigenin significantly inhibited breast cancer metastasis to lungs without affecting the tumor growth of incubated 4T1 breast cancer cells. Pectolinarigenin could also recruit CD8+ T cells to mediate tumor immune response. Furthermore, pectolinarigenin markedly impaired cancer cell migration and invasion by down-regulating phosphorylated-Stat3, and expression of matrix metalloproteinase (MMP)-2, MMP-9, while up-regulating the expression of TIMP2[5]. Treatment of pectolinarigenin inhibited cell viability and cell migration of NPC C666-1 cells in concentration- and time-dependent manner. The in vivo experiment of subcutaneous xenograft mice model also indicated that the administration of pectolinarigenin could decrease the tumor growth of NPC (Nasopharyngeal cancer) and no severe toxicity was observed[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.91mL

3.18mL

1.59mL

31.82mL

6.36mL

3.18mL
参考文献

[1]Juckmeta T, Thongdeeying P, Itharat A. Inhibitory Effect on β -Hexosaminidase Release from RBL-2H3 Cells of Extracts and Some Pure Constituents of Benchalokawichian, a Thai Herbal Remedy, Used for Allergic Disorders. Evid Based Complement Alternat Med. 2014;2014:828760.

[2]Lim H, Son KH, et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7.

[3]Lim H, Son KH, Chang HW, Bae K, Kang SS, Kim HP. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7

[4]Deng Y, Zhang Q, Li Y, Wang L, Yang S, Chen X, Gan C, He F, Ye T, Yin W. Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS-mitochondrial apoptotic pathway in melanoma cells. Oncol Lett. 2020 Oct;20(4):116

[5]Li Y, Gan C, Zhang Y, Yu Y, Fan C, Deng Y, Zhang Q, Yu X, Zhang Y, Wang L, He F, Xie Y, Ye T, Yin W. Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis. Front Pharmacol. 2019 Oct 10;10:1195

[6]Wang C, Cheng Y, Liu H, Xu Y, Peng H, Lang J, Liao J, Liu H, Liu H, Fan J. Pectolinarigenin Suppresses the Tumor Growth in Nasopharyngeal Carcinoma. Cell Physiol Biochem. 2016;39(5):1795-1803