Thiabendazole

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Chemical Structure| 148-79-8 同义名 : 2-(4-噻唑基)苯并咪唑 ;Tiabendazole; 2-(4-Thiazolyl)benzimidazole; Mintesol; Thiabendazol; Thibendole; TBZ; NSC 525040; NSC 90507
CAS号 : 148-79-8
货号 : A557117
分子式 : C10H7N3S
纯度 : 98+%
分子量 : 201.248
MDL号 : MFCD00005587
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(248.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 1 mg/mL clear

PO 0.5% CMC-Na 41 mg/mL suspension

生物活性
描述 Thiabendazole, an orally administered benzimidazole fungicide, possesses repellent and anticancer properties. It is also known to cause developmental malformations and is used for research modeling purposes.[1][2][3][4][5]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.97mL

0.99mL

0.50mL

24.84mL

4.97mL

2.48mL

49.69mL

9.94mL

4.97mL
参考文献

[1]Budetić M, et al. Review of Characteristics and Analytical Methods for Determination of Thiabendazole. Molecules. 2023 May 6;28(9):3926.

[2]Zhang, J., et al., Thiabendazole, a well-known antifungal drug, exhibits anti-metastatic melanoma B16F10 activity via inhibiting VEGF expression and inducing apoptosis. Pharmazie, 2013. 68(12): p. 962-8.

[3]Cha, H.J., et al., Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol, 2012. 10(8): p. e1001379.

[4]Park J, et al. Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish. Environ Int. 2023 Jun;176:107973.

[5]Elgebaly SA, et al. Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease. Am J Pathol. 1984 May;115(2):204-11.