产品说明书
Tetrahydropalmatine HCl
 |
同义名 : | 盐酸延胡乙素 ;DL-Tetrahydropalmatine hydrochloride;Gindarine hydrochloride;1-Tetrahydropalmitine HCl;Tetrahydropalmatine hydrochloride |
| CAS号 : | 6024-85-7 | |
| 货号 : | A556038 | |
| 分子式 : | C21H26ClNO4 | |
| 纯度 : | 98+% | |
| 分子量 : | 391.889 | |
| MDL号 : | MFCD00156231 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 25 mg/mL(63.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 4 mg/mL(10.21 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. It suppresses activation of the NF-kB signaling pathway, which results in regulation of IL-8 expression and specifically blocks the ERK1=2 and p38 MAPK signaling pathways. L-THP results in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP causes activation of caspase and resulted in apoptosis. l-THP possesses a blocking effect on dopamine D1 and D2 receptors and voltage-sensitive Ca2+ channels. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.55mL 0.51mL 0.26mL |
12.76mL 2.55mL 1.28mL |
25.52mL 5.10mL 2.55mL |
