产品说明书
Taurocholic acid sodium salt hydrate
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同义名 : | 牛胆酸钠 ;Sodium taurocholate hydrate;N-Choloyltaurine sodium salt hydrate |
| CAS号 : | 345909-26-4 | |
| 货号 : | A555499 | |
| 分子式 : | C26H46NNaO8S | |
| 纯度 : | 97% | |
| 分子量 : | 555.7 | |
| MDL号 : | MFCD00150132 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(215.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(179.95 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Taurocholic acid (TCA) sodium, a conjugation of cholic acid with taurine, is one of the main bile acids that is elevated in liver disease. In pretreated gingival fibroblasts and HSC-2 cells, TCA considerably reduced the expression of IL1β, IL6, and IL8. TCA has anti-inflammatory activity in gingival fibroblasts, human oral squamous cell carcinoma cells and macrophages in vitro[2]. TCA increased the expression of α-SMA, type I collagen, and TLR4 in LX-2 cells (Hepatic stellate cells). TCA promoting liver cirrhosis is likely through activating hepatic stellate cells via upregulating TLR4 expression[3]. An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric musoca in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa under stress was dose-dependent[4]. Long-term supplementation with small doses of TCA was demonstrated to improve glucose metabolism in a diabetic rat model and may be a potential target for diabetes control[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.80mL 0.36mL 0.18mL |
9.00mL 1.80mL 0.90mL |
18.00mL 3.60mL 1.80mL |
| 参考文献 |
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