产品说明书

KW-2478

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Chemical Structure| 819812-04-9 同义名 : -
CAS号 : 819812-04-9
货号 : A554986
分子式 : C30H42N2O9
纯度 : 95+%
分子量 : 574.663
MDL号 : MFCD21609267
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 190 mg/mL(330.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

30% propylene glycol+5% Tween 80+65% water 10 mg/mL suspension

生物活性
描述 KW-2478 functions as an Hsp90 inhibitor, displaying an IC50 of 3.8 nM against Hsp90α. It exhibits anti-proliferative effects on multiple myeloma (MM) and non-Hodgkin’s lymphoma (NHL), with GI50 values as follows: 0.30 μM (OPM-2/GFP), 0.34 μM (KMS-11), 0.39 μM (RPMI 8226), 0.12 μM (NCI-H929), 0.36 μM (Raji), 0.098 μM (SR), and 0.33 μM (SC-1). Moreover, KW-2478 impedes the transcription of c-Maf and Cyclin D1 genes primarily through the inhibition of Cdk9 activity [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.74mL

0.35mL

0.17mL

8.70mL

1.74mL

0.87mL

17.40mL

3.48mL

1.74mL
参考文献

[1]Nakashima T, et al. New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells. Clin Cancer Res. 2010 May 15;16(10):2792-802.