Kinetin riboside

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Chemical Structure| 4338-47-0 同义名 : 动力精核苷 ;N6-Furfuryladenosine;NSC 120958
CAS号 : 4338-47-0
货号 : A554446
分子式 : C15H17N5O5
纯度 : 99%+
分子量 : 347.326
MDL号 : MFCD00037987
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(719.78 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Kinetin riboside exhibits activities that hinder cell growth and induce apoptosis in a range of human cancer cell lines. It effectively curbs the proliferation of HCT-15 human colon cancer cells, with the inhibition becoming more pronounced with increasing doses (IC50=2.5 μM)[1]. Kinetin riboside triggers cell death processes in HeLa and B16F-10 melanoma cells. It compromises the mitochondrial membrane integrity, leading to cytochrome c release and caspase-3 activation. The exposure to kinetin riboside results in increased levels of Bad and decreased levels of Bcl-2[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.88mL

0.58mL

0.29mL

14.40mL

2.88mL

1.44mL

28.79mL

5.76mL

2.88mL
参考文献

[1]Rajabi M, et al. Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line. Nucleosides Nucleotides Nucleic Acids. 2012;31(6):474-81.

[2]Choi BH, et al. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45.