Pim1/AKK1-IN-1

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Chemical Structure| 1093222-27-5 同义名 : LKB1/AAK1 dual inhibitor
CAS号 : 1093222-27-5
货号 : A553998
分子式 : C20H13N5O
纯度 : 98%
分子量 : 339.35
MDL号 : MFCD15528944
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(147.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Pim1 AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively and also inhibits MPSK1 and TNIK.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.47mL

5.89mL

2.95mL
参考文献

[1]Bamborough P, Drewry D, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.