PNU-282987 free base

产品说明书

Print
Chemical Structure| 711085-63-1 同义名 : PNU 282987
CAS号 : 711085-63-1
货号 : A551216
分子式 : C14H17ClN2O
纯度 : 99%+
分子量 : 264.751
MDL号 : MFCD08703110
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PNU-282987 (free base) is a highly potent agonist of α7 nicotinic acetylcholine receptors (nAChRs), with an EC50 of 154 nM. It also functions as a functional antagonist of the 5-HT3 receptor, with an IC50 of 4541 nM. PNU-282987 (free base) is applicable in research pertaining to both the central and peripheral nervous systems [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.89mL

3.78mL

1.89mL

37.77mL

7.55mL

3.78mL
参考文献

[1]Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.