产品说明书

Eupatorin

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Chemical Structure| 855-96-9 同义名 : NSC 106402
CAS号 : 855-96-9
货号 : A549169
分子式 : C18H16O7
纯度 : 98%
分子量 : 344.315
MDL号 : MFCD00016929
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(726.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Eupatorin, a natural product isolated and purified from the herbs of Eupatorium semiserratum, inhibits cell proliferation in human tumor cells, has meaningful anti-inflammatory property which may be utilized in the development of anti-inflammatory treatments, and induces cell death imediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.52mL

2.90mL

1.45mL

29.04mL

5.81mL

2.90mL
参考文献

[1]Estevez S, Marrero MT, et al. Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway. PLoS One. 2014 Nov 12;9(11):e112536.

[2]Doleckova I, Rarova L, et al. Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. Fitoterapia. 2012 Sep;83(6):1000-7.