Tyrosine kinase-IN-1

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Chemical Structure| 705946-27-6 同义名 : -
CAS号 : 705946-27-6
货号 : A546835
分子式 : C26H28FN5O
纯度 : 99%+
分子量 : 445.532
MDL号 : MFCD30533354
存储条件:

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(112.23 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Tyrosine kinase-IN-1 is a versatile tyrosine kinase inhibitor, exhibiting IC50 values of 4 nM for KDR, 20 nM for Flt-1, 4 nM for FGFR1, and 2 nM for PDGFRα[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.22mL

2.24mL

1.12mL

22.45mL

4.49mL

2.24mL

参考文献

[1]Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985