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Mebhydrolin napadisylate

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Chemical Structure| 6153-33-9 同义名 : Mebhydroline 1,5-naphthalenedisulfonate salt;Diazoline;Omeril;Incidal;Diazolin
CAS号 : 6153-33-9
货号 : A545251
分子式 : C48H48N4O6S2
纯度 : 98%
分子量 : 841.048
MDL号 : MFCD00083420
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(4.76 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mebhydrolin is a specific histamine H1-receptor antagonist and is studied in comparison to chlorpromazine, the archetypal phenothiazine[1]. During an ethanol interaction study, Mebhydrolin exhibits an antihistaminic effect[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.19mL

0.24mL

0.12mL

5.94mL

1.19mL

0.59mL

11.89mL

2.38mL

1.19mL
参考文献

[1]O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7.

[2]Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.