产品说明书

Falnidamol

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Chemical Structure| 196612-93-8 同义名 : Bibx 1382;BIBX 1382 BS
CAS号 : 196612-93-8
货号 : A543629
分子式 : C18H19ClFN7
纯度 : 99%+
分子量 : 387.842
MDL号 : MFCD09838900
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(77.35 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • EGFR/ErbB1
描述 BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM) and displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.58mL

0.52mL

0.26mL

12.89mL

2.58mL

1.29mL

25.78mL

5.16mL

2.58mL
参考文献

[1]Solca FF, Baum A, et al. Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9. Epub 2004 Jun 15.

[2]Solca FF, Baum A, et al. Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.