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RP-64477

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Chemical Structure| 135239-65-5 同义名 : -
CAS号 : 135239-65-5
货号 : A542357
分子式 : C29H42N2O3S
纯度 : 98%
分子量 : 498.72
MDL号 : MFCD00902351
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(14.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RP-64477 is identified as a powerful inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT), an enzyme essential for cholesterol esterification. It demonstrates inhibitory effects across a variety of species and tissues, with IC50 values ranging from 6 to 283 nM, indicating a broad spectrum of activity without noticeable differences between species or tissues. Additionally, RP-64477 shows significant inhibition in human cell lines derived from hepatic (HepGZ), intestinal (CaCo-2), and monocytic (THP-1) origins, with IC50s of 503, 113, and 180 nM, respectively. It does not inhibit rat PCEH or LCAT up to concentrations of 200 μM and 20 μM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.03mL

2.01mL

1.00mL

20.05mL

4.01mL

2.01mL
参考文献

[1]Bello AA, et al. RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21.