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(-)-Dizocilpine maleate

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Chemical Structure| 121917-57-5 同义名 : (-)-MK-801 maleate;(−)-MK-801 (maleate);(-)-MK 801 (Maleate);(-)-MK 801 hydrogen maleate;C13737
CAS号 : 121917-57-5
货号 : A542047
分子式 : C20H19NO4
纯度 : 98%
分子量 : 337.369
MDL号 : MFCD00082466
存储条件:

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(311.23 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 8 mg/mL(23.71 mM),配合低频超声,并水浴加热至45℃助溶

无水乙醇: 25 mg/mL(74.1 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

动物实验配方:
生物活性
靶点
  • NMDA receptor

    NMDA receptor, Ki:30.5 nM

描述 (-)-MK 801 maleate is the enantiomer of (+)-MK-801, which is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.82mL

2.96mL

1.48mL

29.64mL

5.93mL

2.96mL

参考文献

[1]Wise-Faberowski L, Pearlstein RD, et al. NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. J Neurosurg Anesthesiol. 2006 Oct;18(4):240-6.

[2]Wong EH, Kemp JA, et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.