Gossypol xAcetate

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Chemical Structure| 732279-26-4 同义名 : -
CAS号 : 732279-26-4
货号 : A541071
分子式 : C32H34O10
纯度 : 98+%
分子量 : 578.606
MDL号 : MFCD00058385
存储条件:

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Gossypol-acetic acid, a polyphenolic compound isolated from the seeds of Gossypium herbaceum L., inhibits Bcl-2 by acting as a BH3 mimetic.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02938520 HIV Infections Phase 2 Phase 3 Active, not recruiting July 7, 2022 -
NCT01315444 Condition Measuring Alkaline T... 展开 >>ide and Filling Symptoms' Questionnaire After Abrupt or Gradual Step Down Cessation of PPI 收起 << Phase 1 Withdrawn - -
NCT00244374 Medication Adherence ... 展开 >> Substance Abuse, Intravenous Risk Behavior Hepatitis A Hepatitis B Hepatitis C 收起 << Not Applicable Completed - United States, California ... 展开 >> University of California San Francisco Medical Cen San Francisco, California, United States, 94143 0939 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.64mL

1.73mL

0.86mL

17.28mL

3.46mL

1.73mL

参考文献

[1]Lin J, Wu Y, et al. Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. Oncol Rep. 2013 Aug;30(2):731-8.

[2]Ciereszko A, Dabrowski K. In vitro effect of gossypol acetate on yellow perch (Perca flavescens) spermatozoa. Aquat Toxicol. 2000 Jun 1;49(3):181-187.