生物活性 | |||
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靶点 |
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描述 | Primidone is a minor first-generation antiepileptic drug, and also remains a first-line treatment of essential tremor. Although it is metabolized in phenyl-ethyl-malondamide and phenobarbital, active metabolites that contribute also to its action, primidone is not a prodrug and is active by itself. Generally accepted therapeutic range for primidone is between 5 and 10 mg/L (23-46 mmol/L)[3]. Primidone, 50 to 1,000 mg/d, reduced the amplitude of essential tremor in both untreated and propranolol-treated patients. Low doses were as effective as high doses. Primidone decreased tremor more than propranolol. A single oral dose (250 mg) decreased tremor by 60% 1 to 7 hours after ingestion, with stable serum primidone levels. Tremor control was lost when phenobarbital was substituted for primidone shows primidone is an effective agent for the treatment of essential tremor[4]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01771523 | Goiter | Not Applicable | Completed | - | Turkey ... 展开 >> Maltepe University School of Medicine, General Surgery Department İstanbul, Turkey, 34843 收起 << |
NCT01816568 | Acute Appendicitis | Not Applicable | Completed | - | - |
NCT01772745 | Gallbladder Disease | Not Applicable | Completed | - | - |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.58mL 0.92mL 0.46mL |
22.91mL 4.58mL 2.29mL |
45.82mL 9.16mL 4.58mL |
参考文献 |
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[4]Koller WC, Royse VL. Efficacy of primidone in essential tremor. Neurology. 1986 Jan;36(1):121-4. |