产品说明书

	同义名 :	NSC248
	CAS号 :	10163-15-2
	货号 :	A537600
	分子式 :	FNa2O3P
	纯度 :	95%
	分子量 :	143.95
	MDL号 :	MFCD00014248
	存储条件：	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Sodium monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02924922	Kidney Neoplasms	Not Applicable	Completed	-	Switzerland ... 展开 >> Klinik für Urologie, Kantonsspital Luzern Luzern, Switzerland, 6000 收起 <<
NCT02753075	Dentin Sensitivity	Not Applicable	Completed	-	United States, Indiana ... 展开 >> GSK Investigational Site Fort Wayne, Indiana, United States, 46825 收起 <<
NCT03733210	Squamous Cell Carcinoma of the... 展开 >> Head and Neck Carcinoma of the Head and Neck 收起 <<	Phase 1	Not yet recruiting	February 7, 2022	United States, California ... 展开 >> Stanford Cancer Institute Palo Alto Not yet recruiting Palo Alto, California, United States, 94304 Contact: Eben L. Rosenthal    650-723-2967    elr@stanford.edu    Principal Investigator: Eben L. Rosenthal 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	6.95mL 1.39mL 0.69mL	34.73mL 6.95mL 3.47mL	69.47mL 13.89mL 6.95mL

参考文献
[1]Farley JR, Tarbaux NM, Lau KH, Baylink DJ. Monofluorophosphate is hydrolyzed by alkaline phosphatase and mimics the actions of NaF on skeletal tissues, in vitro. Calcif Tissue Int. 1987 Jan;40(1):35-42. [2]Pearce EI. Biochemistry of monofluorophosphate. Caries Res. 1983;17 Suppl 1:21-35.