产品说明书

Leptomycin B

Print
Chemical Structure| 87081-35-4 同义名 : CI 940;LMB;NSC 364372;Mantuamycin;Elactocin
CAS号 : 87081-35-4
货号 : A536845
分子式 : C33H48O6
纯度 : 99%+
分子量 : 540.731
MDL号 : MFCD06795848
存储条件：

粉末 Sealed in dry,Store in freezer, under -70°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(194.18 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Leptomycin B (CI 940; LMB) is a potent inhibitor of protein nuclear export, inactivating CRM1/exportin 1 through covalent modification at a cysteine residue. It has been identified as a potent antifungal antibiotic that impedes the eukaryotic cell cycle[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.85mL

0.37mL

0.18mL

9.25mL

1.85mL

0.92mL

18.49mL

3.70mL

1.85mL
参考文献

[1]N Kudo, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9112-7.

[2]Sarah C Mutka,et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009 Jan 15;69(2):510-7.

[3]Zhongwei Liu, et al.Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27.

[4]Sarah C Mutka, et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009 Jan 15;69(2):510-7.