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Etelcalcetide HCl

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Chemical Structure| 1334237-71-6 同义名 : AMG 416 hydrochloride;KAI-4169 hydrochloride;Velcalcetide;KAI 4169;Etelcalcetide (hydrochloride);Etelcalcetide HCl;Etelcalcetide hydrochloride
CAS号 : 1334237-71-6
货号 : A536362
分子式 : C38H74ClN21O10S2
纯度 : 99%+
分子量 : 1084.712
MDL号 : MFCD32004547
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(92.19 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Etelcalcetide hydrochloride is the hydrochloride salt of etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is administered intravenously at the end of each dialysis session. It functions by binding to and activating the calcium-sensing receptor (CaSR) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.92mL

0.18mL

0.09mL

4.61mL

0.92mL

0.46mL

9.22mL

1.84mL

0.92mL
参考文献

[1]Block GA, Bushinsky DA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.

[2]Subramanian R, Zhu X, et al. Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide). Drug Metab Dispos. 2016 Aug;44(8):1319-31.