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Ciproxifan maleate

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Chemical Structure| 184025-19-2 同义名 : FUB 359 maleate;Ciproxifan (maleate);FUB 359
CAS号 : 184025-19-2
货号 : A534590
分子式 : C20H22N2O6
纯度 : 99%+
分子量 : 386.399
MDL号 : MFCD06411563
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(271.74 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 3 mg/mL(7.76 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
靶点

  • H3 receptor

    Histamine H3 receptor, IC50:9.2 nM
描述 iproxifan maleate (FUB 359 maleate) is a potent, selective, orally bioavailable, and competitive antagonist of the histamine H3 receptor, demonstrating an IC50 of 9.2 nM. It exhibits low apparent affinity at other receptor subtypes and is applicable for research into aging disorders and Alzheimer's disease [1][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.88mL

5.18mL

2.59mL
参考文献

[1]Ligneau X, et, al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998 Nov;287(2):658-66.

[2]Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72.